{"id":2624,"date":"2015-06-04T18:56:00","date_gmt":"2015-06-04T18:56:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=2624"},"modified":"2020-11-30T19:42:00","modified_gmt":"2020-11-30T19:42:00","slug":"disease-burden-of-chronic-hepatitis-c-in-brazil","status":"publish","type":"post","link":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/disease-burden-of-chronic-hepatitis-c-in-brazil\/","title":{"rendered":"Disease burden of chronic hepatitis C in Brazil"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"75\" height=\"100\" src=\"https:\/\/cdafound.org\/wp-content\/uploads\/2015\/06\/Brazilian_Journal_Cover_75x100.png\" alt=\"Journal Cover\" class=\"wp-image-3189\"\/><\/figure><\/div>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26051505\">Ferreira PR, Brand\u00e3o-Mello CE, Estes C, Gon\u00e7ales J\u00fanior FL, Coelho HS, Razavi H, Cheinquer H, Wolff FH, Ferraz ML, Pessoa MG, Mendes-Correa MC. Disease burden of chronic hepatitis C in Brazil. Braz J Infect Dis. 2015 Jul-Aug;19(4):363-8. doi: 10.1016\/j.bjid.2015.04.004. Epub 2015 Jun 4. PMID: 26051505.<\/a><\/p>\n\n\n\n<br>\n\n\n\n<br>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Background<\/h3>\n\n\n\n<p>Hepatitis C virus infection is a major cause of cirrhosis; hepatocellular carcinoma; and liver transplantation. The aim of this study was to estimate hepatitis C virus disease progression and the burden of disease from a nationwide perspective.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Methods<\/h3>\n\n\n\n<p>Using a model developed to forecast hepatitis C virus disease progression and the number of cases at each stage of liver disease; hepatitis C virus-infected population and associated disease progression in Brazil were quantified. The impact of two different strategies was compared: higher sustained virological response and treatment eligibility rates (1) or higher diagnosis and treatment rates associated with increased sustained virological response rates (2).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Results<\/h3>\n\n\n\n<p>The number of infected individuals is estimated to decline by 35% by 2030 (1,255,000 individuals); while the number of cases of compensated (n = 325,900) and decompensated (n = 45,000) cirrhosis; hepatocellular carcinoma (n = 19,100); and liver-related deaths (n = 16,700) is supposed to peak between 2028 and 2032. In strategy 2; treated cases increased over tenfold in 2020 (118,800 treated) as compared to 2013 (11,740 treated); with sustained virological response increased to 90% and treatment eligibility to 95%. Under this strategy; the number of infected individuals decreased by 90% between 2013 and 2030. Compared to the base case; liver-related deaths decreased by 70% by 2030; while hepatitis C virus-related liver cancer and decompensated cirrhosis decreased by 75 and 80%; respectively.<\/p>\n\n\n\n<p><strong>Countries:<\/strong> Brazil<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ferreira PR, Brand\u00e3o-Mello CE, Estes C, Gon\u00e7ales J\u00fanior FL, Coelho HS, Razavi H, Cheinquer H, Wolff FH, Ferraz ML, Pessoa MG, Mendes-Correa MC. Disease burden of chronic hepatitis C in Brazil. Braz J Infect Dis. 2015 Jul-Aug;19(4):363-8. doi: 10.1016\/j.bjid.2015.04.004. Epub 2015 Jun 4. PMID: 26051505. Summary Background Hepatitis C virus infection is a major cause [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":3105,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[10],"publication-author":[],"class_list":["post-2624","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-hcv"],"acf":[],"_links":{"self":[{"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/posts\/2624","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/comments?post=2624"}],"version-history":[{"count":5,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/posts\/2624\/revisions"}],"predecessor-version":[{"id":3434,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/posts\/2624\/revisions\/3434"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/media\/3105"}],"wp:attachment":[{"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/media?parent=2624"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/categories?post=2624"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/tags?post=2624"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/publication-author?post=2624"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}