{"id":4348,"date":"2020-04-02T19:22:00","date_gmt":"2020-04-02T19:22:00","guid":{"rendered":"https:\/\/cdafound.org\/?p=4348"},"modified":"2021-07-12T19:27:54","modified_gmt":"2021-07-12T19:27:54","slug":"optimization-of-hepatitis-c-virus-screening-strategies-by-birth-cohort-in-italy","status":"publish","type":"post","link":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/optimization-of-hepatitis-c-virus-screening-strategies-by-birth-cohort-in-italy\/","title":{"rendered":"Optimization of hepatitis C virus screening strategies by birth cohort in Italy"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"75\" height=\"100\" src=\"https:\/\/cdafound.org\/wp-content\/uploads\/2011\/07\/Liver_International_Generic_Cover_75x100.png\" alt=\"Journal Cover\" class=\"wp-image-3487\"\/><\/figure><\/div>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32078234\/\">Kondili LA, Gamkrelidze I, Blach S, Marcellusi A, Galli M, Petta S, Puoti M, Vella S, Razavi H, Craxi A, Mennini FS; PITER collaborating group. Optimization of hepatitis C virus screening strategies by birth cohort in Italy. Liver Int. 2020 Jul;40(7):1545-1555. doi: 10.1111\/liv.14408. Epub 2020 Apr 2. PMID: 32078234; PMCID: PMC7384106.<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<p>Optimization of hepatitis C virus screening strategies by birth cohort in Italy<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Background and Aims<\/h3>\n\n\n\n<p>Cost-effective screening strategies are needed to make hepatitis C virus (HCV) elimination a reality. We determined if birth cohort screening is cost-effective in Italy.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><br>Methods<\/h3>\n\n\n\n<p>A model was developed to quantify screening and healthcare costs associated with HCV. The model-estimated prevalence of undiagnosed HCV was used to calculate the antibody screens needed annually, with a \u20ac25 000 cost-effectiveness threshold. Outcomes were assessed under the status quo and a scenario that met the World Health Organization&#8217;s targets for elimination of HCV. The elimination scenario was assessed under five screening strategies.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><br>Results<\/h3>\n\n\n\n<p>A graduated birth cohort screening strategy (graduated screening 1: 1968- 1987 birth cohorts, then expanding to 1948-1967 cohorts) was the least costly. This strategy would gain approximately 144 000 quality-adjusted life years (QALYs) by 2031 and result in an 89.3% reduction in HCV cases, compared to an 89.6%, 89.0%, 89.7% and 88.7% reduction for inversed graduated screening, 1948-77 birth cohort, 1958-77 birth cohort and universal screening, respectively. Graduated screening 1 yielded the lowest incremental cost-effectiveness ratio (ICER) of \u20ac3552 per QALY gained.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><br>Conclusions<\/h3>\n\n\n\n<p>In Italy, a graduated screening scenario is the most cost-effective strategy. Other countries could consider a similar birth cohort approach when developing HCV screening strategies.<\/p>\n\n\n\n<p><strong>Countries:<\/strong> Italy<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Kondili LA, Gamkrelidze I, Blach S, Marcellusi A, Galli M, Petta S, Puoti M, Vella S, Razavi H, Craxi A, Mennini FS; PITER collaborating group. Optimization of hepatitis C virus screening strategies by birth cohort in Italy. Liver Int. 2020 Jul;40(7):1545-1555. doi: 10.1111\/liv.14408. Epub 2020 Apr 2. PMID: 32078234; PMCID: PMC7384106. Summary Optimization of hepatitis [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":3486,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[10],"publication-author":[],"class_list":["post-4348","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publication","tag-hcv"],"acf":[],"_links":{"self":[{"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/posts\/4348","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/comments?post=4348"}],"version-history":[{"count":1,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/posts\/4348\/revisions"}],"predecessor-version":[{"id":4349,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/posts\/4348\/revisions\/4349"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/media\/3486"}],"wp:attachment":[{"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/media?parent=4348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/categories?post=4348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/tags?post=4348"},{"taxonomy":"publication-author","embeddable":true,"href":"https:\/\/dnc-test.myddns.me\/cda-foundation\/cdafound.org\/wp-json\/wp\/v2\/publication-author?post=4348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}